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The Computational, Organoid, and Microphysiological Systems Initiative

Corrine Kliment, MD, PhD

Corrine Kliment, MD, PhD

Lung organoids/slices modeling mitochondrial lung disease

Contact ckliment@pitt.edu

Technology Expertise

  • Primary lung cell isolation (airway and alveolar)
  • Alveolar organoids
  • Precision cut lung slices
  • Air-liquid interface cultures
  • Mitochondrial analysis (including Seahorse Bioenergetic Analysis)
  • In Vivo and Ex Vivo exposure systems (cigarette smoke)

Disease Focus

  • Mitochondrial dysfunction in:
  • Chronic lung disease
  • COPD
  • Pulmonary fibrosis
  • Aging